In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.

"The Tempest "is one of Shakespeare's most popular plays, both in the classroom and in the theatre, and this revision brings the Arden Third series edition right up-to-date. A completely new section of the introduction discusses new thinking about Shakespeare's sources for the play and examines his treatment of colonial themes, as well as covering key productions since this edition was first published in 1999. Most importantly it looks at Julie Taymor's ground-breaking 2010 film starring Helen Mirren as "Prospera"

Alden and Virginia Vaughan's edition of "The Tempest "is highly valued for its authority and originality and this revision brings it up-to-date, making it even more relevant and useful to studetns and theatre practitioners.

Transatlantic Encounters examines the diverse origins and experiences of approximately 175 American Indians and Inuits who traveled to the British Isles before the American Revolution. Their homelands ranged from northern Canada to Brazil, their ages from infant to nonagenarian, their statuses from slave (the largest category) to 'emperor', their occupations from warrior to missionary. Some American natives died soon after arrival, but others remained as long as fourteen years and returned home; still others, their arrival and death dates undocumented, may have endured long lives abroad. And always, Indians and Inuits fascinated the British people, whether the Americans were captives or on commercial display, interpreters-in-training, or voluntary voyagers to petition the monarch and tour Britain's famous sites. British artists painted their portraits and eminent writers invoked them in plays and essays. In the imperial crisis of 1776, Indian diplomats who had been to London would staunchly support the British Empire.

Transatlantic Encounters examines the diverse origins and experiences of approximately 175 American Indians and Inuits who traveled to the British Isles before the American Revolution. Their homelands ranged from northern Canada to Brazil, their ages from infant to nonagenarian, their statuses from slave (the largest category) to "emperor," their occupations from warrior to missionary. Some American natives died soon after arrival, but others remained as long as fourteen years and returned home; still others, their arrival and death dates undocumented, may have endured long lives abroad. And always, Indians and Inuits fascinated the British people, whether the Americans were captives or on commercial display, interpreters-in-training, or voluntary voyagers to petition the monarch and tour Britain's famous sites. British artists painted their portraits and eminent writers invoked them in plays and essays. In the imperial crisis of 1776, Indian diplomats who had been to London would staunchly support the British Empire.

Shakespeare and American Life celebrates the extraordinary English poetOs influence on American culture D whether high, low, or middlebrow D to mark the 150th anniversary of Henry FolgerOs birth and the 75th anniversary of the great library he and Emily created for Shakespearean scholarship. A sampler of such scholarship is here presented by nine essays that offer contexts for the multitude of images and objects on display in the Folger LibraryOs Great Hall during the spring and summer of 2007, many of them D and a few additional images D reproduced in this catalogue. The essays explore ShakespeareOs influence on AmericaOs cultural history from a variety of perspectives. Chronologically, they range from the colonial period, to the adoption of Shakespeare as an OAmerican geniusO in the nineteenth century, to twentieth-century musical comedy, film, theater, and finally to Shakespeare as we know him in twentyfirst century America. Culturally, the essays range from the academic (about editors and scholars), to the theatrical (ShakespeareOs continuous presence on the American stage), to the popular (the appropriation of Shakespeare as a popular icon in advertising, folk art, and kitsch)."

Have you ever wondered if the stories from your family's past were really true? When Mark Stephens takes a week long trip to visit his elderly grandmother, Emily Goodman, he is confronted by the reality of his family's secret past. She reveals how her father Frank's desire to control her life and the lives of her family members made them virtual prisoners. Emily's father, Frank Vandermeer, is a man trying to escape his past; the mysterious death of his first wife, a witness who speaks from the grave, and a child who vanishes into thin air. When a private investigator, hired by his ex-father-in law, shows up unexpectedly, Frank fears his past may have finally caught up to him. Helen, Frank's second wife, is trapped by her own fears and bound by her religious beliefs concerning marriage. Son Frank Jr., manipulated by his father to become heir to the family business, struggles under the pressure. Levi, the middle child, longs for the freedom to make his own path in life. Daughter Emily struggles to overcome her father's manipulation, so she can marry the man she loves. Fate conspires to bring the struggles of Frank and his family to a climactic conclusion. In the process of sharing her secret, Emily and Mark's bond grows deeper. In turn, she helps him come to an important decision in his own life. The ending will make you think about what really matters most in life.

In contrast to most accounts of Puritan-Indian relations, New England Frontier argues that the first two generations of Puritan settlers were neither generally hostile toward their Indian neighbors nor indifferent to their territorial rights. Rather, American Puritans-especially their political and religious leaders-sought peaceful and equitable relations as the first step in molding the Indians into neo-Englishmen. With a new introduction, this third edition affords the reader a clear, balanced overview of a complex and sensitive area of American history. "Vaughan has exhaustively examined the records and written a book of indispensable value to any student of colonial New England."-New York Times Book Review Alden T. Vaughan, Professor Emeritus of History at Columbia University is the author or editor of numerous books, including The Puritan Tradition in America, 1620-1730, New England's Prospect, and Puritans among the Indians.

The Tempest, the last play Shakespeare wrote without a collaborator, has become a key text in school and university curricula, not simply in early modern literature courses but in postcolonial and history programs as well. One of Shakespeare's most frequently performed plays, The Tempest is also of great interest to a general audience. This volume will outline the play's most important critical issues and suggest new avenues of research in a format accessible to students, teachers, and the general reader.

The Tempest contains sublime poetry and catchy songs, magic and low comedy, while it tackles important contemporary concerns: education, power politics, the effects of colonization, and technology. In this guide, Alden T. Vaughan and Virginia Mason Vaughan open up new ways into one of Shakespeare's most popular, malleable and controversial plays.

These eight reports by white settlers held captive by Indians gripped the imagination not only of early settlers but also of American writers through our history. "Puritans among the Indians" presents, in modern spelling, the best of the New England narratives. These both delineate the social and ideological struggle between the captors and the settlers, and constitute a dramatic rendition of the Puritans' spiritual struggle for redemption.

Many students of our national character would agree that, for better or worse, the Puritan tradition had an enormous effect on the assumptions and aspirations of today's Americans. This book tells the story, largely through the participants' own words, of the emergence of that tradition. It provides a broad range of primary documents--religious, political, social, legal, familial, and economic--for an understanding of Puritanism in early New England. Originally published in 1972, it is reissued here with a new introduction and two new documents: extracts from Anne Hutchinson's trial and from John Winthrop's "Experiencia."

This important new collection brings together ten of Alden Vaughan's essays about race relations in the British colonies. Focusing on the variable role of cultural and racial perceptions on colonial policies for Indians and African Americans, the essays include explorations of the origins of slavery and racism in Virginia, the causes of the Puritans' war against the Pequots, and the contest between natives and colonists to win the other's allegiance by persuasion or captivity. Less controversial but equally important to understanding the racial dynamics of early America are essays on early English paradigmatic views of Native Americans, the changing Anglo-American perceptions of Indian color and character, and frontier violence in pre-Revolutionary Pennsylvania. Published here for the first time are an extensive expose of slaveholder ideology in seventeenth-century Barbados, the second half of an essay on Puritan judicial policies for Indians, a general introduction, and headnotes to each essay. All previously published pieces have been revised to reflect recent scholarship or to address recent debates.
Challenging standard interpretations while probing previously-ignored aspects of early American race relations, this convenient and provocative collection by one our most incisive commentators will be required reading for all scholars and students of early American history.

The full range of literary traditions comes to life in the Twayne Critical Essays Series. Volume editors have carefully selected critical essays that represent the full spectrum of controversies, trends and methodologies relating to each author's work. Essays include writings from the author's native country and abroad, with interpretations from the time they were writing, through the present day.

Each volume includes:

-- An introduction providing the reader with a lucid overview of criticism from its beginnings -- illuminating controversies, evaluating approaches and sorting out the schools of thought

-- The most influential reviews and the best reprinted scholarly essays

-- A section devoted exclusively to reviews and reactions by the subject's contemporaries

-- Original essays, new translations and revisions commissioned especially for the series

-- Previously unpublished materials such as interviews, lost letters and manuscript fragments

-- A bibliography of the subject's writings and interviews

-- A name and subject index